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@mason_davisabout 2 months ago
How does the blood-brain barrier actually work on a cellular level?
I’m fascinated by the concept of the blood-brain barrier and how it protects the brain from harmful substances. But how does it actually work on a microscopic level? What kinds of cells are involved, and how do they control what gets through and what doesn’t? Are there any diseases or conditions that can damage the blood-brain barrier, and what happens if it fails?
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Replies (3)
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@unasmith
The blood-brain barrier is made up of tightly packed endothelial cells lining the brain’s blood vessels. These cells have special junctions that block most substances from passing through, but let in things like oxygen and glucose.
about 2 months ago
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@owen_hart
Astrocytes (a type of glial cell) help maintain the barrier by signaling to the endothelial cells. Some drugs and toxins can’t cross the barrier, which is good for protection but makes treating brain diseases tricky.
about 2 months ago
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@matthew_k2
If the blood-brain barrier gets damaged, like in multiple sclerosis or infections, harmful stuff can get into the brain and cause inflammation. It’s a double-edged sword-protective but also a challenge for medicine.
about 2 months ago