Ejaculatory duct

Medically Reviewed by Anatomy Team

The ejaculatory duct is a paired structure in the male reproductive system, where each duct forms from the union of the duct of the seminal vesicle and the vas deferens. The ejaculatory ducts are located within the prostate gland and run through its central zone. They open into the prostatic urethra at the seminal colliculus, a small elevation on the posterior wall of the urethra. Positioned just behind the bladder and passing through the central part of the prostate, the ejaculatory ducts serve as a pathway for sperm and seminal fluid to enter the urethra before ejaculation.

Structure and Anatomy

The ejaculatory ducts are important components of the male reproductive system, responsible for carrying semen into the urethra. Below is a detailed description of their anatomical structure and location.

Formation of the Ejaculatory Duct

Each ejaculatory duct is formed by the union of two key structures:

  • Duct of the Seminal Vesicle: The seminal vesicle produces seminal fluid, and its duct merges with the vas deferens to form the ejaculatory duct. This duct carries seminal fluid from the seminal vesicle.
  • Vas Deferens (Ductus Deferens): The vas deferens transports sperm from the epididymis (where sperm are stored and mature) in the testes. It joins the duct of the seminal vesicle near the base of the bladder to form the ejaculatory duct.

Location

The ejaculatory ducts are located in the pelvic cavity within the prostate gland, specifically in the central zone of the prostate. Their positioning is as follows:

  • Superiorly: They originate at the base of the prostate, just behind the bladder. This is where the vas deferens and seminal vesicles unite.
  • Within the Prostate: The ducts pass through the central zone of the prostate, which surrounds them as they travel through the gland.
  • Inferiorly: The ducts descend toward the prostatic urethra, where they empty at the seminal colliculus, a small prominence on the posterior wall of the prostatic urethra.

Structure

The ejaculatory ducts are thin, tubular structures that are typically about 2 cm long and 1 mm in diameter. They are formed by:

  • Smooth Muscle: The walls of the ejaculatory ducts contain smooth muscle fibers that help propel their contents during ejaculation.
  • Lined with Epithelium: The inner surface of the ejaculatory duct is lined with pseudostratified columnar epithelium, which is similar to the lining of other parts of the reproductive tract.
  • Surrounded by Fibrous Tissue: The ducts are surrounded by connective tissue within the prostate, which helps support their structure and position within the gland.

Pathway Through the Prostate

As the ejaculatory ducts pass through the prostate gland, they travel within the central zone of the prostate. The central zone provides protection for the ducts and allows them to transport seminal fluid and sperm through the prostate without interference.

Seminal Colliculus: The ejaculatory ducts open into the prostatic urethra at the seminal colliculus, which is a small raised area on the posterior wall of the urethra. The openings of the ducts are small slit-like orifices that allow semen to pass into the urethra during ejaculation.

Relationship to Surrounding Structures

  • Bladder: The ejaculatory ducts are positioned just behind the bladder, and their origin is near the base of the bladder.
  • Prostate Gland: The ducts travel through the central zone of the prostate, which protects and supports them as they make their way to the urethra. This zone is known for its relative resistance to conditions like prostate cancer, unlike the peripheral zone.
  • Urethra: The ejaculatory ducts open directly into the prostatic urethra, which carries both urine and semen to the outside of the body.

Length and Diameter

  • Length: The ejaculatory ducts are approximately 2 cm in length. This short length allows for the quick transport of seminal fluid and sperm into the urethra during ejaculation.
  • Diameter: The diameter of the ejaculatory ducts is around 1 mm, making them narrow tubes that are specifically designed to carry small volumes of fluid efficiently.

Blood Supply

The blood supply to the ejaculatory ducts comes from branches of the inferior vesical artery, which also supplies the seminal vesicles and prostate. The internal pudendal artery may also contribute to the vascular supply of the ducts.

Venous Drainage: Venous drainage occurs through the prostatic venous plexus, which drains into the internal iliac veins.

Nerve Supply

The ejaculatory ducts receive autonomic nerve innervation from the pelvic plexus, which contains both sympathetic and parasympathetic fibers.

  • Sympathetic Innervation: The sympathetic nervous system plays a key role in triggering ejaculation by stimulating the contraction of smooth muscle surrounding the ejaculatory ducts.
  • Parasympathetic Innervation: Parasympathetic fibers from the pelvic plexus regulate secretory activity and provide support for the overall function of the ducts during sexual activity.

Microscopic Anatomy

At the microscopic level, the ejaculatory ducts are lined with pseudostratified columnar epithelium, which aids in the passage of seminal fluid. The walls of the ducts are supported by:

  • Smooth Muscle: This muscle layer contracts during ejaculation, helping to expel semen into the urethra.
  • Fibrous Connective Tissue: Surrounding the smooth muscle layer, fibrous connective tissue provides structural support to the duct as it passes through the prostate.

Development and Embryology

The ejaculatory ducts develop from the mesonephric (Wolffian) ducts during fetal development, which also give rise to other structures of the male reproductive system, such as the vas deferens and seminal vesicles.

Embryonic Origin: The ejaculatory ducts form as a result of the connection between the vas deferens (which arises from the mesonephric duct) and the seminal vesicle. This connection happens as the male reproductive organs develop in response to the presence of androgens.

Anatomical Variations

The structure of the ejaculatory ducts can vary slightly between individuals. In rare cases, anatomical abnormalities or obstructions in the ducts can occur, potentially impacting reproductive function.

In summary, the ejaculatory ducts are formed by the union of the vas deferens and duct of the seminal vesicle. They are located within the prostate gland, pass through the central zone, and open into the prostatic urethra at the seminal colliculus. These small, smooth muscle-lined ducts are critical for transporting sperm and seminal fluid from the reproductive organs into the urethra. The ducts are supported by surrounding connective tissue, supplied by the inferior vesical artery, and innervated by autonomic nerves from the pelvic plexus.

Function

The ejaculatory ducts play a crucial role in the male reproductive system by transporting seminal fluid and sperm into the urethra for ejaculation. Below is a detailed description of the key functions of the ejaculatory ducts.

Transport of Seminal Fluid and Sperm

The primary function of the ejaculatory ducts is to transport sperm and seminal fluid from the male reproductive organs to the prostatic urethra.

Sperm Transport from the Vas Deferens:

  • The vas deferens carries sperm from the epididymis (where sperm mature and are stored) in the testes. Once sperm reach the terminal part of the vas deferens, they enter the ejaculatory ducts.
  • The ejaculatory ducts then transport the sperm toward the urethra, where it will mix with seminal fluid and be expelled during ejaculation.

Seminal Fluid Transport from the Seminal Vesicles

  • The seminal vesicles produce a fluid rich in fructose, enzymes, and other nutrients that are vital for sperm viability and motility. The fluid from the seminal vesicles enters the ejaculatory ducts through the duct of the seminal vesicle.
  • This seminal fluid mixes with the sperm inside the ejaculatory duct before both are expelled into the prostatic urethra during ejaculation.

Contribution to Semen Formation

The ejaculatory ducts are critical for the final formation of semen, as they serve as a mixing point for fluids from the vas deferens (sperm) and seminal vesicles (seminal fluid).

Mixing of Sperm and Seminal Fluid:

  • Inside the ejaculatory ducts, sperm from the vas deferens is combined with seminal fluid from the seminal vesicles. This process forms the bulk of semen, which is further augmented by prostatic fluid when it reaches the prostatic urethra.
  • The combination of these fluids is essential for the creation of semen, which provides an optimal environment for sperm, supporting their movement, nourishment, and protection as they prepare for fertilization.

Formation of Seminal Plasma:

The seminal plasma formed in the ejaculatory ducts provides the necessary medium for sperm to travel through the male urethra and into the female reproductive system. The seminal plasma contains fructose for sperm energy, prostaglandins that aid in motility, and other components that help protect sperm from the acidic environment of the female reproductive tract.

Passage into the Prostatic Urethra

The ejaculatory ducts are responsible for delivering semen into the prostatic urethra, where it is further combined with prostatic secretions before being expelled from the body.

Opening into the Prostatic Urethra

  • The ejaculatory ducts empty into the prostatic urethra at the seminal colliculus, a raised area on the posterior wall of the urethra. This is where the mixed semen from the ejaculatory ducts is joined by prostatic fluid.
  • The smooth muscle contractions of the prostate, stimulated by the sympathetic nervous system, push the contents of the ejaculatory ducts into the urethra during ejaculation.

Preparation for Ejaculation

Once the semen reaches the prostatic urethra, it mixes with prostatic fluid, which contributes additional enzymes and nutrients, particularly prostate-specific antigen (PSA). This fluid helps liquefy semen and makes it less viscous, allowing sperm to move more freely and improving their chances of reaching an egg for fertilization.

Role in Ejaculation

The ejaculatory ducts are critical during the process of ejaculation, helping to expel semen from the male reproductive system.

Smooth Muscle Contractions

  • The walls of the ejaculatory ducts contain smooth muscle, which contracts during ejaculation. These contractions are controlled by the sympathetic nervous system, particularly through signals from the inferior hypogastric plexus.
  • The smooth muscle contractions forcefully push the semen through the ejaculatory ducts and into the urethra. This propulsion is necessary for the efficient expulsion of semen from the reproductive system during ejaculation.

Coordinated Muscle Contractions in the Prostate: During ejaculation, the contractions of the ejaculatory ducts are synchronized with the contractions of the prostatic smooth muscle, allowing for a coordinated expulsion of fluids from the prostate and seminal vesicles into the urethra. This ensures the proper mixing of fluids and efficient ejaculation.

Preventing Retrograde Flow of Semen

The ejaculatory ducts play an important role in preventing the retrograde flow of semen into the bladder.

Closure of the Internal Urethral Sphincter

  • During ejaculation, the internal urethral sphincter, located at the neck of the bladder, contracts to prevent semen from flowing backward into the bladder (a condition known as retrograde ejaculation). This sphincter contraction is coordinated with the function of the ejaculatory ducts.
  • The ejaculatory ducts ensure that semen flows forward into the urethra, while the internal urethral sphincter prevents any backflow, allowing the semen to exit the body through the penile urethra.

Regulation of Sperm and Seminal Fluid Flow

The ejaculatory ducts act as a regulatory pathway that controls the release of sperm and seminal fluid.

Controlled Release of Sperm and Seminal Fluid

  • The ejaculatory ducts ensure that sperm and seminal fluid are released only during ejaculation. The smooth muscle around the ducts contracts to push the contents into the urethra at the appropriate time, ensuring that sperm are delivered in conjunction with the necessary fluids to form semen.
  • The sympathetic nervous system regulates this process, ensuring that the ejaculatory ducts function only during sexual arousal and ejaculation.

Coordination with Other Reproductive Structures

The ejaculatory ducts coordinate with other parts of the male reproductive system, such as the prostate gland, vas deferens, and seminal vesicles, to ensure that semen is properly formed and delivered during ejaculation. This ensures that all components of semen are mixed and expelled at the right time.

Embryological Role

The ejaculatory ducts develop from the mesonephric ducts (Wolffian ducts) during fetal development. They connect the reproductive system (testes, vas deferens) with the urinary system (urethra).

Embryological Function

  • The formation of the ejaculatory ducts during embryogenesis links the male reproductive organs to the urethra, establishing the route through which sperm and seminal fluid will be expelled during ejaculation.
  • This developmental connection between the mesonephric ducts and the urethra ensures that the male reproductive system is properly connected to the urinary system, allowing for the dual-purpose function of the urethra in carrying both urine and semen.

Clinical Significance

The ejaculatory ducts play a crucial role in the male reproductive system, and any dysfunction or obstruction can lead to significant clinical issues:

  • Ejaculatory Duct Obstruction (EDO): A common condition affecting the ejaculatory ducts is obstruction, which can result from congenital defects, inflammation, infection, or scar tissue. EDO can lead to symptoms such as painful ejaculation, reduced semen volume (oligospermia), or even infertility. It can be diagnosed using imaging techniques like transrectal ultrasound (TRUS) and treated through procedures like transurethral resection of the ejaculatory ducts (TURED).
  • Retrograde Ejaculation: Dysfunction of the ejaculatory ducts, combined with issues at the bladder neck, may cause retrograde ejaculation, where semen flows backward into the bladder rather than being expelled through the urethra. This condition can lead to fertility problems.
  • Seminal Vesicle Dysfunction: As the ejaculatory ducts are closely connected to the seminal vesicles, any issues with the vesicles, such as infection or inflammation (seminal vesiculitis), can affect the function of the ejaculatory ducts, impacting semen quality and ejaculation.

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